SOX10

SOX10
Identifikatorar
Andre namn	SOX10, DOM, PCWH, WS2E, WS4, WS4C, SRY-box 10, SRY-box transcription factor 10, SOX-10
Eksterne ID-ar	OMIM: 602229 MGI: 98358 HomoloGene: 5055 GeneCards: SOX10
Genplassering (menneske)
Kromosom	Menneskekromosom 22
Ende	37,987,422 bp
Genplassering (mus)
Kromosom	Musekromosom 15
Ende	79,049,440 bp
RNA-uttrykksmønster
	Top expressed in
	complexus olivaris inferior; ; nervus suralis; ; inferior ganglion of vagus nerve; ; trigeminusganglion; ; spinalganglion; ; nucleus subthalamicus; ; ventral tegmental area; ; glandula parotis; ; globus pallidus lateralis; ; superior vestibular nucleus;
	Meir referanseuttrykksdata
	; ;
	More reference expression data
Genontologi
Molekylær funksjon	GO:0001105 transcription coactivator activity; transcription factor binding; chromatin binding; GO:0001948, GO:0016582 proteinbinding; identical protein binding; promoter-specific chromatin binding; DNA-binding; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Sellekomponent	cytoplasma; nukleoplasma; cellekjerne; kromatin; mitokondrium; mitochondrial outer membrane; membran; extrinsic component of mitochondrial outer membrane;
Biologisk prosess	GO:0009373 regulation of transcription, DNA-templated; GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; morfogenese av anatomisk struktur; transcription, DNA-templated; stamcelledifferensiering; GO:0045996 negative regulation of transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; negative regulation of Schwann cell proliferation; GO:1901313 positiv regulering av genekspresjon; positive regulation of myelination; cellular response to progesterone stimulus; GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; oligodendrocyte development; central nervous system myelination; oligodendrocyte differentiation; in utero embryonic development; neural crest cell migration; morfogenese av epitel; positive regulation of neuroblast proliferation; utvikling av sentralnervesystem; peripheral nervous system development; positive regulation of gliogenesis; celledifferensiering; melanocyte differentiation; lacrimal gland development; negativ regulering av apoptoseprosess; GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; cellemodning; enteric nervous system development; digestive tract morphogenesis; utviklingsvekst; morphogenesis of a branching epithelium; negative regulation of canonical Wnt signaling pathway;
	Kjelder:Amigo / QuickGO
Ortologar
	6663
	20665
	ENSG00000100146
	ENSMUSG00000033006
	P56693
	Q04888
	NM_006941
	NM_011437
	NP_008872
	NP_035567
	Wikidata
sjå/endra menneske	sjå/endra mus

SOX10 er ein transkripsjonsfaktor i SOX-genfamilien. Han er naudsynt for utvikling av både Schwann-seller og oligodendrocyttar.^[5] Han er òg naudsynt for utviklinga og vedlikehaldet av melanocyttar.^[6]

SOX10 har ulike bindingssete i oligodendrocyttar og Schwann-seller. I oligodendrocyttar vekselverkar SOX10 med protein som transkripsjonsfaktorane OLIG1, OLIG2 og myelinregulerande faktor. SOX10 bunde til OLIG1 aktiverer avskrivinga av genet til basisk myelinprotein (MBP). I Schwann-seller vekselverkar SOX10 med protein som transkripsjonsfaktoren tidleg vekstresponsprotein 2.^[5]^[7]

Kjelder[endre | endre wikiteksten]

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000100146 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000033006 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ ^5,0 ^5,1 Lopez-Anido, Camila; Sun, Guannan; Koenning, Matthias; Srinivasan, Rajini; Hung, Holly A.; Emery, Ben; Keles, Sunduz; Svaren, John (2015). «Differential Sox10 genomic occupancy in myelinating glia». Glia 63 (11): 1897. doi:10.1002/glia.22855.
↑ Fufa, Temesgen D.; Harris, Melissa L.; Watkins-Chow, Dawn E.; Levy, Denise; Gorkin, David U.; Gildea, Derek E.; Song, Lingyun; Safi, Alexias; Crawford, Gregory E.; Sviderskaya, Elena V.; Bennett, Dorothy C.; McCallion, Andrew S.; Loftus, Stacie K.; Pavan, William J. (2015). «Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes». Human Molecular Genetics 24 (19): 5433. PMID 26206884. doi:10.1093/hmg/ddv267.
↑ Li, H.; Lu, Y.; Smith, H. K.; Richardson, W. D. (2007). «Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes». Journal of Neuroscience 27 (52): 14375. PMID 18160645. doi:10.1523/JNEUROSCI.4456-07.2007.

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[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000100146 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000033006 - Ensembl, May 2017

[3] «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lopez-Anido2015-5] 5,0 ^5,1 Lopez-Anido, Camila; Sun, Guannan; Koenning, Matthias; Srinivasan, Rajini; Hung, Holly A.; Emery, Ben; Keles, Sunduz; Svaren, John (2015). «Differential Sox10 genomic occupancy in myelinating glia». Glia 63 (11): 1897. doi:10.1002/glia.22855.

[6] Fufa, Temesgen D.; Harris, Melissa L.; Watkins-Chow, Dawn E.; Levy, Denise; Gorkin, David U.; Gildea, Derek E.; Song, Lingyun; Safi, Alexias; Crawford, Gregory E.; Sviderskaya, Elena V.; Bennett, Dorothy C.; McCallion, Andrew S.; Loftus, Stacie K.; Pavan, William J. (2015). «Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes». Human Molecular Genetics 24 (19): 5433. PMID 26206884. doi:10.1093/hmg/ddv267.

[7] Li, H.; Lu, Y.; Smith, H. K.; Richardson, W. D. (2007). «Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes». Journal of Neuroscience 27 (52): 14375. PMID 18160645. doi:10.1523/JNEUROSCI.4456-07.2007.

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